Clonal cooperativity in heterogenous cancers
نویسندگان
چکیده
منابع مشابه
Cooperativity in biological systems
Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...
متن کاملThe role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome
BACKGROUND The advent of rapid and inexpensive sequencing technology allows scientists to decipher heterogeneity within primary tumours, between primary and metastatic sites, and between metastases. Charting the evolutionary history of individual tumours has revealed drivers of tumour heterogeneity and highlighted its impact on therapeutic outcomes. DISCUSSION Scientists are using improved se...
متن کاملEvidence for common clonal origin of multifocal lung cancers.
BACKGROUND Lung cancer is the most common cause of cancer death in the United States. Multiple anatomically separate but histologically similar lung tumors are often found in the same patient. The clonal origin of multiple lung tumors is uncertain. METHODS We analyzed 70 lung tumors from 30 patients (23 females and seven males) who underwent surgical resection for lung epithelial tumors, of w...
متن کاملcooperativity in biological systems
living organisms can sense and respond to external and internal stimuli. response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...
متن کاملElectron Microscopy in Heterogenous catalysis
Electron Microscope is popular and powerful techniques used to characterize heterogeneous catalysts. In heterogeneous catalysis, frequently used catalysts are metal particles supported on an oxidic material. The size of the metal particles plays a crucial role for the catalyst efficiency, and the determination of size distribution is one of the main tasks of electron microscopy in catalysis. Th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2017
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2016.08.028